Journal Articles |
| Hormones-Men article #1: Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. |
| RESULTS: Reduction of body fat, increase in fat free mass, no change in body weight improvement of leg/knee extension and handgrip strength, improved bone mineral density at the lumbar spine but not the femoral neck, reduced total cholesterol with no change in LDL (low density lipoprotein and a significant reduction in HDL (high density lipoprotein in studies with high baseline Testosterone. Sensitivity and meta-regression analysis revealed that the dose/type of T used, in particular the possibility of aromatization, explained the heterogeneity in findings observed on bone density and HDL-cholesterol among studies. |
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| Hormones-Men article #2: Testosterone and prostate safety |
| There is mounting evidence that low serum T is associated with greater prostate cancer risk, and more worrisome features of prostate cancer. In conclusion, the available evidence strongly suggests that T therapy is safe for the prostate. Given that the population at risk for T deficiency overlaps with the population at risk for prostate cancer, it is strongly recommended that men undergoing T therapy undergo regular monitoring for prostate cancer. |
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| Hormones-Men article #3: Does testosterone therapy increase the risk of prostate cancer? |
| CONCLUSIONS: Mounting evidence demonstrates that there is a lack of association between testosterone therapy and prostate cancer progression. Testosterone therapy may be prescribed for men for whom it was once not considered. Careful monitoring of patients with hypogonadism who are receiving testosterone therapy is imperative. Well-designed, large-scale prospective clinical trials are necessary to adequately address prostate safety in hypogonadal men receiving testosterone therapy. |
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| Hormones-Men article #4: Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men |
| CONCLUSION: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body FM and increased total body FFM and total body and thigh skeletal muscle mass. Further studies are needed to determine the impact of these body compositional changes on markers of metabolic and cardiovascular risk. |
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| Hormones-Men article #5: Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey. |
| CONCLUSIONS: Under our assumptions, a large majority (87.8%) of 97 men in our groups with AD were not receiving treatment despite adequate access to care. The reasons for this are unknown but could be due to unrecognized AD or unwillingness to prescribe testosterone therapy. |
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